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Pregnancy planning also affects durationmedication-specific washout periods apply (approximately 2 months for semaglutide, 1 month for tirzepatide/dulaglutide, and immediate discontinuation for liraglutide when pregnancy is recognized)

Proper site rotation becomes particularly important with daily injections to prevent localized tissue changes

The lowest doses produced the smallest increases

When insulin signaling improves, some patients experience more consistent weight loss trajectories and reduced metabolic inflammation

These include conditions like high blood pressure, type 2 diabetes, or high cholesterol
