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This process involves the activation of microglia to the M1 phenotype in the dorsal horn, triggering the release of pro-inflammatory cytokines, including TNF and IL-1/6, as well as glutamate, leading to neuroinflammation, synaptic hyperexcitability, and central sensitization

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Nearly 42% of all adults in the U.S

September 2010

The information is publicly visible: Because anyone can access FAERS, media coverage, or social media chatter can amplify a perceived link, which in turn may drive more selfreports, reinforcing the appearance of an association

Haqq, [email protected] These authors have contributed equally to this work This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers