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Patient-derived human islets from male and female cadaveric donors were 3D-cultured in solubilised extracellular matrix gel in co-culture with the same donor PBMCs, and incubated with cytokines (IL-1, TNF-, IFN-) for 2448 h in the presence of vehicle or increasing concentrations of the CB1R blocker JD-5037

Clinical trials have shown th

There is growing interest in the relationship between Alzheimers disease (AD) and diabetes mellitus (DM), and the glucagon-like peptide-1 receptor (GLP-1R) may be an important link between these two diseases

Introduction: from Adverse Events to Beneficial Events The mighty adverse event (AE) case report form (CRF) had its humble beginning in 1938 when

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High glucose levels and Gs-coupled receptor stimulation synergistically triggered insulin and GLP-1 secretion