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Phentermine may have a role in specific scenariossuch as short-term use (typically 12 weeks or less) in patients with no cardiac historybut evidence increasingly favors GLP-1 monotherapy as a first-line approach due to better safety margins and sustained weight loss

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New additions (Sodium glucose transporter 2 inhibitors [SGLT2i/Flozin] and non-steroidal mineralocorticoid antagonists [nsMRAs]) to the bedrock of RAS inhibition (RASi) covered more territory and improved outcomes

Traveling with semaglutide and phentermine If you are taking phentermine alongside semaglutide, phentermine is a controlled substance in many jurisdictions

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In Eli Lillys Phase 3 TRIUMPH-1 trial, the 12 mg group lost an average of 28.3% body weight over 80 weeks, with 45.3% achieving at least 30% weight loss