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Its mechanism of action involves delaying stomach emptying and slowing intestinal motility, leading to prolonged satiety

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And weight gain is often driven by multiple factors: hormones, insulin resistance, medications, sleep deprivation, stress, and muscle loss

An Alternative Low-Cost Option: Kongo If brand-name GLP-1s are out of reachwhether due to cost, insurance restrictions, or accesscompounded medications offer another path forward

Insulin resistance & prediabetes, National Institute of Diabetes and Digestive and Kidney Diseases (2025) Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial, The Lancet Diabetes & Endocrinology (2024) With prediabetes, action is the best medicine, American Diabetes Association Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes2025, Diabetes Care (2025) About the Lifestyle Change Program, CDC (2024)

Fernandez-Millan E, Martin MA, Goya L, Lizarraga-Mollinedo E, Escriva F, Ramos S, et al