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NAION represents an equally devastating complication, causing sudden and irreversible vision loss when blood flow to the optic nerve stops, requiring patients to seek medical attention immediately

Full exclusion criteria are listed in the Electronic Supplementary Material (ESM

These reports are not proof

The main practical concern is overlapping GI side effects, since both can cause nausea, diarrhea, or stomach upset

Glycemic improvements in patients with type 2 diabetes occur relatively quickly, with fasting glucose reductions often observable within the first week and hemoglobin A1c improvements becoming apparent over 812 weeks

Rotating between all three areas weekly prevents the development of nodules, scarring, and uneven fat distribution that can interfere with medication absorption patterns