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In contrast to these studies, there were four particular studies which concluded a higher rate of aspiration and regurgitation events among GLP-1 RA users compared to non-users (Australian Diabetes Society, National Association of Clinical Obesity Services, Gastroenterological Society of Australia, and Australian and New Zealand College of Anaesthetists n.d.)

Weight health acknowledges that certain individuals possess a higher threshold for storing subcutaneous fat than others

Most patients notice improvement within the first few weeks

Therefore, the ability of GLP-1 receptor agonists to reach central targets via the nasal route should be interpreted cautiously and in direct relation to their physicochemical properties, including size, enzymatic stability, and affinity for transporter systems