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Peptides such as Semaglutide, Tirzepatide, and Retatrutide have shown significant effects in both preclinical and clinical models, making them valuable tools for obesity and diabetes-related investigations

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These innovative medications are effective and increasingly accessible to everyone, including those with limited incomes

Those were originally intended for use with diabetes and function by stimulating the release of insulin from the pancreas, which lowers blood sugar, as well as slowing the digestion of food in order to reduce appetite, which promotes weight loss

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In an attempt to assess CV efficacy of oral semaglutide after demonstrating its CV safety in the PIONEER-6 trial, a large CVOT ( N = 9,650) is currently ongoing (SOUL trial) to compare the risk of MACE composite outcome with oral semaglutide vs