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Description
This dual-compound approach works best for patients with genetic variants showing suboptimal single-pathway response or those who've plateaued on tirzepatide monotherapy

This would translate to 51 fewer recurrences per 1,000 patient treated with fundoplication (95% CI 90 fewer to 57 more)

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By targeting all three at once, Retatrutide 50mg produces a broader range of metabolic effects including appetite suppression, improved insulin sensitivity, and direct liver fat reduction that single or dual receptor agonists cannot fully replicate

doi: 10.1002/jrsm.1232
