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Understanding GLP-1 and Its Role in Weight Management GLP-1, a significant hormone, contributes to weight management by affecting appetite control and blood sugar regulation

Highly diversified expansions shaped the evolution of membrane bound proteins in metazoans

Isoelectric points (pI) of the analogues were determined using isoelectric focusing gel electrophoresis (Figure S1), and the determined values are given in Figure 1D in the column next to the solubility chart

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From the doseinhibition curves obtained in vitro we can estimate that this equates to a GLP-1(936) concentration of 30 pmol/l, in remarkably good agreement with the plasma GLP-1 concentration observed in vivo