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The weight-loss story around GLP-1s is real

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In type 2 diabetes, the lipid-buffering capacity of WAT is dysregulated due to nutrient surplus in excess of adipose storage capacity, reduced insulin-mediated suppression of FFAs release, lowered adipose tissue perfusion, and impaired recruitment of lipoprotein lipase (LPL) which is responsible for hydrolysis and uptake of triglycerides [45]

People with hypothyroidism also experience higher appetite and slower stomach emptying, which makes traditional calorie restriction feel impossible

doi: 10.1038/s41467-020-15686-y 221 RyanJPKarimHTAizensteinHJHelblingNL

Cell 185(14):2478-2494.e28 [DOI] [PMC free article] [PubMed] [Google Scholar] Zheng Z, Zong Y, Ma Y, Tian Y (2024) Glucagon-like peptide-1 receptor: mechanisms and advances in therapy