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Metformin has been shown to reduce heart attack risk by one-third compared to other common diabetes drugs like sulfonylureas (glipizide) or thiazolidinediones (rosiglitazone)

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While this supports immune cell activation and enhances pathogen clearance, excessive activation may contribute to tissue injury and immunosuppression (52)

Originally developed for diabetes management, these GLP-1 receptor agonists have shown impressive results in clinical trials helping many patients lose 1521% of their body weight under controlled study conditions