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84 The reasons for this are not clear, but it has been suggested that chronic constipation may be a symptom of diabetes complications, and longitudinal studies are needed to evaluate the temporal relationship between the onset of chronic constipation and other diabetes complications

doi: 10.1016/j.clinthera.2011.04.024 [DOI] [PubMed] [Google Scholar] 123.Jyrkas J, Tolonen A

GLP-1/GIP medications help by: Reducing appetite Increasing fullness Decreasing food cravings However, studies have demonstrated that over time: Appetite suppression may soften slightly Portion sizes may slowly increase Energy needs fall as body weight decreases When calorie intake and calorie expenditure find a new equilibrium , weight loss slows or stops creating a plateau

2008;29(Suppl 2):S20-S34

Side effects that have been reported with Ozempic can include: nausea and vomiting flatulence constipation diarrhea abdominal pain fatigue injection site reactions In rare instances, you may also experience serious side effects such as: vision changes kidney problems gall bladder disease severe allergic reactions an increased risk of thyroid cancer hypoglycemia (low blood sugar) pancreatitis (inflammation of the pancreas) In some cases, you may be unable to prevent facial side effects from Ozempic

Long-term efficacy and safety of anti-obesity treatment: where do we stand