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In addition, treatment with tirzepatide increased odds of discontinuation of study drug due to adverse events

Lilly said nothing is known about the impuritys short- or long-term effects in humans, including possible effects on receptor interaction, toxicity, immune reactions, or drug disposition

Tirzepatide or placebo was initiated at a dose of 2.5 mg once weekly and was increased in 2.5 mg increments every 4 weeks through the 20week dose escalation period

10.1056/NEJMoa2032183 67 WitkowskiM.WilkinsonL.WebbN.WeidsA.GlahD.VrazicH

In the study, the average weight loss was about 15% for 5 mg, 19.5% for 10 mg, and 20.9% for 15 mg in adults with obesity or who are overweight without type 2 diabetes

Inject a day early before your trip, establish that new day as your temporary schedule, and shift back after you return if desired