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It remains the leading cause of ESKD in adults, with the global prevalence of DM in adult ESKD patients reaching 29.7% in 2015 [7]

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In adult NHANES (National Health and Nutrition Examination Survey) participants with diagnosed diabetes, glycemic control declined after more than a decade of progress, associated with a resurgence in vascular diabetic complications [23]

Overall, JM appears to be in good metabolic control
GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have transformed diabetes and weight management, but emerging evidence links these medications to increased gallbladder complications
The risk profile is not only clinical but also regulatory , requiring vigilance at the dispensing stage
