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It is not about taking less of the same thing and hoping for the same result
GLP-1 agonists are incredibly effective at reducing appetite and increasing feelings of fullness (satiety)

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Triple hormone receptor agonist retatrutide for obesity. New England Journal of Medicine

We are more confident of the decreased risk in GLP-1 medications compared to metformin and insulin. Because this was a retrospective, large database study, it relied on accurate ICD coding by clinicians, notes Dr