gray glp 1 How Long To Take Semaglutide for Weight Loss GLP-1 medications mimic the effects

TriNetX conducts logistic regression analysis to obtain propensity scores for each cohort

doi: 10.1016/j.eclinm.2024.102624

[DOI] [PubMed] [Google Scholar] 28.ONeil P.M., Birkenfeld A.L., McGowan B., Mosenzon O., Pedersen S.D., Wharton S., Carson C.G., Jepsen C.H., Kabisch M., Wilding J.P.H

Lancet 399 , 394405 (2022) R.V

We measured mRNA levels of GLP-1R, PC1/3, PC2 and Pdx1 in cells by PCR, and the trend was also consistent with the trend of their protein expression (Figures 5HK)

If thats true, then stopping GLP-1 RAs would deliver a double whammy: the agent causing increased satiety (and subsequent weight loss) has gone and the bodys normal GLP-1 response to eating is also suppressed