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The scientific rationale for dual incretin receptor activation emerged from physiological research demonstrating that GIP and GLP-1 have complementary but distinct roles in metabolic regulation

[DOI] [PubMed] [Google Scholar] 19.Wilke T, et al

Because these peptides are highly potent, even minor deviations in the reconstitution process can lead to significant physiological shifts in the research subject

Moreover, GLP-1R cascade also has interactions to regulatory proteins involved in the insulin receptor cascades such as the insulin receptor substrates (IRS) and the PI3K involved in the positive regulation for survival, metabolism and proliferation of beta pancreatic cells as well as apical glucose transport in peripheral tissues

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Images were acquired with a FEI Tecnai Spirit Twin (120 kV) equipped with a Tietz F416 camera using Leginon 36