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A pilot clinical trial by Atkins suggests pairing GLP1 use with targeted macronutrients, especially protein and fiber, may support healthier body composition and a lower-carb diet with higher protein and fiber intake is well tolerated

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Diabetes Care 2023;46:24951.ArticlePubMedPMCPDF 45

Incorporation of a trifluoromethyl group at the 6-position of the tetrahydropyran ring in omarigliptin (with a (2R, 3S, 5R, 6S) configuration) was found not only to enhance the pharmacokinetic profile in mice but also to maintain robust DPP-4 inhibitory activity

Medicine 2025;104:40(e44917)

While we typically get electrolytes through food and beverages, reduced food intake or increased fluid losses from GI side effects can make it harder to maintain that crucial balance