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TK wrote the first manuscript draft

We included trials recruiting adults with type 2 diabetes regardless of their background glucose-lowering treatment, defined as the glucose-lowering therapy used both in the intervention and control arms after the randomisation

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The dual receptor advantage Semaglutide activates one receptor

Weaning off tirzepatide gradually rather than stopping abruptly may reduce the rebound appetite effect and make planned breaks more manageable

They can be mild to moderate, but they gradually dissipate for most people as their body adjusts to the medication
