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Furthermore, GLP-1 analogs may restore insulin secretion by activating the GLP-1 receptor (GLP-1R)-Gs signals because GLP-1 analogs overcome SSTR5-Gi signals in pancreatic -cells under the condition of suppressed insulin production and spare suppressed incretin secretion from intestinal L-cells 27

Nello specifico, stato ipotizzato un possibile ruolo anti-infiammatorio di GLP1 attraverso meccanismi quali la down-regolazione di citochine coinvolte nei processi di flogosi come interleuchina 1 (IL-1), interleuchina 6 (IL-6) e tumor necrosis factor alfa (TNF-\(\alpha \)) e linibizione dei processi di infiltrazione delle cellule infiammatorie nei tessuti [911]

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46 A recent study showed that GLP-1 nanomedicine is effective in treating intestinal inflammation in a mouse model of colitis, by preserving epithelial architecture and inhibition of cytokine production

doi: 10.1001/archinte.1994.00420010131015

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