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Patients with contraindications to GLP-1 agonists may explore older weight-loss medications like phentermine or orlistat, or consider non-pharmacologic approaches like intensive lifestyle modification and bariatric surgery consultation

The burden of mortality attributable to diabetes: realistic estimates for the year 2000

Leipold G, Tth R, Hrsfalvi P, Lczi L, Trk M, Keszthelyi A, et al

All statistics and clinical interpretations are sourced from published Phase 2 and Phase 3 trial results as of October 2025

Nausea is the most common side effect associated with GLP-1 medications

While GLPs are not intended to treat PCOS specifically, they are increasingly considered under close medical supervision