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As soon as Mojsov and Deanna Deery, Weir's technician, injected the peptide into the perfused rat, they were astonished to see it secrete insulin, even when given in a tiny dose, the same concentration as the one that circulates in the blood

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doi: 10.1016/j.bmcl.2015.12.024

At the same time, concerns persist regarding the gastrointestinal side-effects commonly associated with GLP-1RAs, which may limit their applicability in patients with coexisting IBD

10.1016/j.molmet.2020.101102 95 NauckM

Regain risk: Once you stop, appetite usually returns and so does the weight
