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The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

In contrast, other effects, including modulation of mitochondrial and ER function, ceramide reduction, macrophage polarization, and suppression of hepatic inflammation via NKT cells, have been primarily demonstrated in preclinical models

DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption

Ive seen 1520% total body weight reduction in patients who follow the complete program

PubMed, Hidayat, K., et al

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