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The LEADER trial with liraglutide and the SUSTAIN-6 trial with semaglutide demonstrated cardiovascular benefits that may be partially mediated through anti-inflammatory mechanisms

Semaglutide binds more effectively to GLP-1 receptors, producing stronger appetite suppression

The most prevalent factors employers take into consideration for GLP-1 drug coverage for obesity care include: Obesity as a risk factor for chronic conditions and associated costs67% Drug shortages47% Impact/effectiveness of cost-control mechanisms47% Existing coverage through government programs40% Long-term costs33% Patient and prescriber demand33%

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Another review of 38 RCTs involving T2D patients observed nausea in 19% of participants treated with GLP-1RAs and vomiting in 7.6%