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The secret sauce is not AI Even as the story of Medvi has created a huge buzz in tech circles there are two aspects of it that are giving people pause

Compared to the active state, ECL1 moves toward helix I by 5 when measured at the N-terminal tip of the helix (C of Q211), and ECL1 residue W214 is reoriented ~180 o from an outside-facing position to a position pointing towards helix I

Food and Drug Administration approved orforglipron which will be marketed as Foundayo. While it may not exactly be like finding the Holy Grail, the drug promises to be hugely successful commercially

We included data from 8 CVOTs and 60,080 patients (72.4% with established cardiovascular disease)