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Pathophysiology Incretin hormones, including GLP-1 and GIP, are gut peptides released after meal intake and are responsible for as much as 70% of post-prandial glucose-dependent insulin secretion from endocrine pancreatic beta-cells and regulation of glucagon secretion to control glucose homeostasis [2123]

As nonselective imaging modalities like magnetic resonance imaging and computed tomography have failed to offer a reliable detection method, cellspecific biomarkers have been investigated and evaluated (Shiue et al., 2004

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