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Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management

Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV
Metabolic rate decreases after weight loss, a phenomenon called metabolic adaptation

The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )
In contrast, Linagliptin is a long-acting drug because of its high degree of binding to dipeptidyl peptidase-4 (DPP-4)

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