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Microglia react to injury through morphological changes, increased proliferation, migration to the target, phagocytosis, activation of the NLRP3 inflammasome, and consequently, the release of proinflammatory mediators [198,201]

PubMed Anderson, S

Patients with type 2 diabetes themselves have an elevated baseline risk of pancreatitis compared to the general population, which complicates the assessment of whether any observed cases are directly attributable to the medication or related to underlying metabolic factors and comorbidities

Causation is harder to prove

In clinical trials for Barth syndrome, evidence suggests the drug is highly effective, yielding a 20-25% improvement in a six-minute walk test and a 40-50% improvement in leg extension strength

JAMA Otolaryngol Head Neck Surg 2022;148(6):568575