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Other important safety considerations include risk of hypoglycaemia when combined with insulin or sulfonylureas, potential gallbladder disease, and the need for monitoring in patients with pre-existing diabetic retinopathy

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Table 1: Physiological roles of GIP and glucagon, and their intended therapeutic effect

The distribution of the GLP-1R is similar to preproglucagon fiber projections with high expression in hypothalamic areas that regulate energy homeostasis, both in rodents and non-human primates (Merchenthaler et al., 1999

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[DOI] [PubMed] [Google Scholar] 184.Rosenstock J, Raccah D, Koranyi L, Maffei L, Boka G, Miossec P, Gerich JE