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Appetite and Weight Loss: Tirzepatide works on the appetite centers in the brain, helping you feel fuller for longer

Mollan SP, Tahrani AA, Sinclair AJ (2021) The potentially modifiable risk factor in idiopathic intracranial hypertension: body weight

While still effective, these results generally fall short of what Mounjaro achieves
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Weight Loss and Cardiovascular Outcomes Although semaglutide led to an average placebo-adjusted weight loss of 8.5% (Semaglutide arm lost 8.5% more body weight than those who took the placebo), its cardiovascular risk reduction was not linked to how much weight patients lost