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[38] Merck & Co., Inc

This is important context when managing expectations of results from taking GLP-1s as well as addressing the internalized weight bias that many of us hold after marinating in diet and weight-biased medical culture

After 48 weeks treatment with two highest doses of retatrutide, 90% of participants had normalisation of liver fat [67]

The pill may be a better starting point for patients who: Have a strong aversion to needles or self-injection Are earlier in their weight loss journey and want to establish habits before committing to injections Prefer a potentially lower-cost option without compromising clinical effectiveness Have a predictable morning routine that accommodates the empty-stomach dosing requirement Prefer not to deal with refrigeration or storage requirements The injection may be a better fit for patients who: Have an irregular schedule that makes consistent morning fasting difficult Take multiple daily oral medications that cannot be spaced 30 minutes from the semaglutide pill Have tried the pill and had suboptimal results due to adherence challenges Are seeking a once-weekly dosing schedule that requires less daily attention Have established cardiovascular disease and benefit from the broader outcomes data behind the injectable form The Frontiers in Endocrinology review noted that oral semaglutide may be especially useful in patients who decline injectable therapy, when injectable medications are unavailable, or as an initial therapy before transitioning to more potent treatment options

2 3 Sanyal AJ, Newsome PN, Kliers I, Ostergaard LH, Long MT, Kjaer MS, et alPhase 3 trial of semaglutide in metabolic dysfunctionassociated steatohepatitis

But what are they and who needs them