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Tesofensine : Originally developed for neurodegenerative disorders, this triple monoamine reuptake inhibitor demonstrated substantial appetite suppression and weight loss in clinical trials

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Appetite suppressionactually a therapeutic effectoften feels like a side effect because the dramatic reduction in hunger can feel unusual if you are accustomed to frequent eating

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Front Immunol 15(3):13104431310455

The researchers suggest that changes in gut microbiome composition, particularly involving Akkermansia muciniphila and Parabacteroides distasonis , may explain the effects on GLP-1 and other gut-brain signaling molecules