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siRNA silencing of -catenin and a dominant negative insertion of TCF7L2 in INS-1 cells (a -cell line) blunted the ability of Ex4 to stimulate -cell proliferation (139), indicating that Wnt signaling is necessary for GLP-1-induced -cell proliferation

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Furthermore, secondary analyses pointed toward possible renoprotective effects, evidenced by a reduction in albuminuria

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