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Dynamic regulation of Ca 2+ cycling proteins of the sarcoplasmic reticulum (SR) is a mechanism to regulate pacemaker rate 48,49

Butler, P
Jastreboff, A.M., et al., Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial

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The drug activates three hormone receptors - GLP-1, GIP and glucagon - earning it the nickname "triple G"
