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An entrepreneur I met in a Substack comment thread about GLP-1s said he heard of associates in high-risk finance jobs underperforming because they are no longer as impulsive

STEP 1 ( 2000 , 68 ) 15% 2,4%

Combination pharmacotherapy with GLP-1RAs and other treatments (e.g., GIP agonists, SGLT2 inhibitors, or amylin analogs) is an exciting frontier for weight and metabolic benefit [79]

Ann Hum Biol

The rate of discontinuation due to adverse events varied from 5% to 19%, predominantly due to gastrointestinal side effects [17]

Theres a long list of reasonable explanations for why semaglutide may have failed, Drucker says