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Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.

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Conclusions Together our results suggest that liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model.

A 68 year old female presented to the ED with epigastric abdominal tenderness for 2 days and 3 episodes of non-bloody emesis of undigested food after eating breakfast