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Even more alarming, some sellers are marketing individual pharmaceutical ingredients directly to consumers through social media and online platforms, encouraging people to mix and inject their own medications at home

For instance, research involving Ozempic (semaglutide) showed an astonishing average weight loss of 14.9% over 68 weekseffectively doubling the results of other weight loss medications on the market (Wilding et al., 2021)

Judicial Panel on Multidistrict Litigation centralized these cases into the Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAS) Products Liability Litigation (MDL 3094) in Pennsylvania federal court to manage the rising number of claims more efficiently

centrally-mediated loss of appetite & increased thermogenic activity GLP-1 receptors are found in regions of the hindbrain and hypothalamus that regulate feeding behavior Centrally mediated GLP-1 effects include: reduction of food intake - resulting in weight loss due to reduced caloric intake activation of sympathetic pathways in the dorsomedial hypothalamus (DMH) and ventromedial nucleus of the hypothalamus (VMH) that increase neuronally mediated thermogenic activity of brown adipose tissue (BAT) resulting in increased energy expenditure with associated weight loss (Contreras et al, 2017

Direct clinical harm data in human nursing infants does not exist because GLP-1 medications have not been studied in breastfeeding populations

But emotionally they had already become strangers