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The E-values were notably high, at 4.51 for all-cause mortality, 2.38 for MACEs, and 2.00 for MAKEs, indicating that the observed associations are unlikely to be explained away by potential confounding (Supplemental Table 7)

* Correspondence: Hesham A

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While GLP-1 receptor agonists externally stimulate this pathway, the human body already possesses intrinsic mechanisms to regulate GLP-1 signaling through the gut microbiome
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