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Because they operate through distinct mechanisms, combining them often produces additive benefits for blood sugar control and weight reduction

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For example, rats administered exendin-4 into the HPCv only decrease their consumption of a high fat/sugar diet 6h after the infusion, but at the 24h timepoint chow intake is also reduced [69]

A reviewer suggested we perform a GWAS for each medication class separately to avoid masking signals, given that tirzepatide targets both GLP-1 and GIP receptors

doi: 10.1111/dom.13034

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