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Substitution of Lys with Arg at position 34 prevents C18 fatty acid binding at the wrong site

[DOI] [PubMed] [Google Scholar] 472.Fehmann H.C., Goke B., Goke R., Trautmann M.E., Arnold R
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The addition of GIP receptor agonism in tirzepatide does not appear to significantly amplify heart rate effects compared to GLP-1-only drugs like semaglutide
