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The black box warning notes that GLP-1s such as Mounjaro are contraindicated for individuals with a history or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

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The investment will focus on: Building oral solid-dose manufacturing capacity Establishing localized supply systems Supporting the production and supply of Orforglipron This project represents one of the largest global manufacturing expansion initiatives in Lillys history

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Lee PH, Stockton MD, Franks AS

It is however an important debate to consider, given the impact it will have on the future drug development ecosystem, as well as clinical practice and patient outcomes