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The medium was then discarded and replaced with fresh medium containing insulin at concentrations of 2, 50, and 1250 nM or ITP at concentrations of 1.25, 2.5, 5, and 10 M

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These data provide an explanation for CNS activation even though monoclonal antibodies have minimal brain penetrance, reaching concentrations of around 0.10.4% of the monoclonal antibody concentrations in the plasma 50,51

Br J Pharmacol 165: 414423, 2012

We intend to hold Catalent accountable for their contract with us as we gain more information on this proposed transaction.