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Some common side effects that Adderall XR vs IR have in common include: Weight loss or reduced appetite Dizziness Difficulty sleeping Dry mouth Headaches Stomach pain or nausea Nervousness Increased heart rate These are all common side effects that can occur with either Adderall ER vs Adderall IR, and often do improve over time as your body gets used to the medication

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doi: 10.1042/BJ20050113

In December 2025, the administration also introduced the BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive hEalth) model, a five year CMS Innovation Center (CMMI) model that intends to expand access to obesity drugs in Medicaid and Medicare by negotiating lower GLP-1 prices with manufacturers

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New England Journal of Medicine, March 2023 In this Perspective piece, researchers at Vanderbilt University create a series of estimates about how much Medicare may have to spend annually on weight-loss drugs if the program eventually covers these drugs