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Carter S, Clifton PM, Keogh JB (2019) The effect of intermittent compared with continuous energy restriction on glycaemic control in patients with type 2 diabetes: 24-month follow-up of a randomised noninferiority trial

The investigation specifically showed that these drugs did not increase the risk of any fractures, confirming their safety profile in clinical practice ( 4.6 Ophthalmological effects 4.6.1 Glaucoma GLP-1R agonists exhibit anti-inflammatory and neuroprotective properties, suggesting they could also be beneficial in neurodegenerative diseases ( A recent registry-based case-control study, summarized in Table 2 , involving 1,961 patients found that the use of GLP-1R agonists is linked to a lower risk of glaucoma (Sterling et al., 2021 (79)

Li M et al

For type 2 diabetes, NICE has established specific criteria for NHS-funded use, including previous treatment history and glycaemic targets

doi: 10.1016/j.peptides.2019.170184 [DOI] [PubMed] [Google Scholar] 131

It has two promising drugs in late stage clinical trials it hopes will give it an edge: an oral weight loss pill, orfoglipron, and a hormone mimicking injection, retatrutide
