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Phenotype of sarcopenic obesity in older individuals with a history of falling

No published safety data for the combination

NICE guidance suggests that couples should be offered fertility assessment if they have not conceived after 12 months of regular unprotected intercourse, or after 6 months if the woman is 36 years or over, or earlier if there are known fertility concerns

Certain natural plant compounds have been shown to support GLP-1 production in lab and animal studies: Flavonoids like (-)-epicatechin (found in dark chocolate) and anthocyanins (from berries and purple veggies) have been shown to increase GLP-1 and improve metabolism via the PKA signaling pathway (Cremonini et al., 2021)

Call 999 or go to your nearest A&E immediately if you experience: Signs of a severe allergic reaction (anaphylaxis), including swelling of the face, lips, tongue, or throat, difficulty breathing, or a widespread rash with collapse Seek urgent medical advice if you experience: Severe or persistent vomiting that prevents you from keeping fluids down Signs of dehydration, including dizziness, dark urine, or significantly reduced urination Severe abdominal pain, particularly if it radiates to the back this may indicate pancreatitis, a rare but serious adverse effect associated with GLP-1 receptor agonists [11] [12] Pain in the upper right abdomen, fever, yellowing of the skin or eyes (jaundice), pale stools, or dark urine these may be signs of a gallbladder problem, such as gallstones or cholecystitis, which have been associated with this class of medicine and with rapid weight loss Symptoms of hypoglycaemia (low blood sugar), such as shakiness, sweating, confusion, or palpitations the risk is higher if you are also taking insulin or a sulfonylurea

The MHRA encourages reporting of any suspected adverse drug reactions through the Yellow Card scheme (yellowcard.mhra.gov.uk)