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The clearest signal comes straight from FDA prescribing information for semaglutide products, which notes that there have been postmarketing reports of acute kidney injury, in some cases requiring hemodialysis, with the majority of reported events occurring in patients who experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea
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The use of incretin mimetics is also recommended as add-on therapy in people with type 2 diabetes and obesity when initial therapy provides insufficient glycaemic control.
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