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Semaglutide is a GLP-1 receptor agonist that helps regulate: Appetite Blood sugar Digestion Feelings of fullness It is widely used for both diabetes management and medical weight loss through physician-guided programs

In clinical trials, Semaglutide GLP-1 has helped patients lose 15 percent or more of their starting body weight over the course of a year

The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549

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From this model, it is estimated that as a result of the competition with icodec for albumin binding locally at the injection site, less than 1% of semaglutide is bound to albumin in the subcutis following IcoSema administration (Alifrangis L., 2025, unpublished data)