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[47] Psychiatric disorders, including a history of psychosis or severe depression, may be relative contraindications due to corticosteroids potential to cause or worsen psychiatric symptoms

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[5] Severe respiratory depression has been reported in a 5-year-old child with ultra-rapid CYP2D6 genotype and obstructive sleep apnea, who received a single 20 mg dose (approximately 1 mg/kg) of tramadol for postoperative pain related to adenotonsillectomy