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Starting at subtherapeutic doses (microdosing protocols) or using compounded formulations with customized titration steps may help patients build tolerance before advancing to standard maintenance doses

van den Broek M, de Heide LJM, Sips FLP et al (2021) Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery

As a result, it may be hazardous to take both treatments simultaneously

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Meanwhile, a post-hoc analysis of the STEP 1 and STEP 4 trials showed that semaglutide 2.4 mg was associated with an approximately 60% reduction of the 10-years risk of T2D according to the Cardiometabolic Disease Staging (CMDS) calculator, regardless of patients baseline glycemic status 74

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